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Sodium Oxamate
CAS No. 565-73-1
Sodium Oxamate ( SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt )
Catalog No. M22595 CAS No. 565-73-1
Sodium Oxamate is an LDH inhibitor.?Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1G | 29 | In Stock |
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Biological Information
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Product NameSodium Oxamate
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NoteResearch use only, not for human use.
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Brief DescriptionSodium Oxamate is an LDH inhibitor.?Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
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DescriptionSodium Oxamate is an LDH inhibitor.?Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.It inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway.NETosis and lactate accumulation during LPS induced sepsis in mice was inhibited by sodium oxamate, LDH inhibitor.
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SynonymsSO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt
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PathwayApoptosis
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TargetApoptosis
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RecptorLDH;CDK;Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number565-73-1
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Formula Weight111.03
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Molecular FormulaC2H2NNaO3
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Purity>98% (HPLC)
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Solubility——
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SMILES[Na+].NC(=O)C([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Awasthi D , Nagarkoti S , Sadaf S , et al. Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis[J]. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019, 1865(12):165542-.
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